Figure 4 | Scientific Reports

Figure 4

From: Local anesthetic bupivacaine induced ovarian and prostate cancer apoptotic cell death and underlying mechanisms in vitro

Figure 4

Bupivacaine treatment reduced cell proliferation and modulated oxidative stress of both ovarian cancer (SKOV-3) and prostate cancer (PC-3) cells.

Cells were treated with 1 mM bupivacaine (Bupi) for 24 h for proliferation study and 4 h treatment for reactive oxygen species (ROS) detection. (A) Ki-67 expression in (A) SKOV-3 cells and (B) PC-3 cells. (C) ROS generation in (C) SKOV-3 cells and (D) PC-3 cells. Data are presented as mean ± SD (n = 4). *P < 0.05; **P < 0.01; ***P < 0.001.

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