Figure 7 | Scientific Reports

Figure 7

From: Local anesthetic bupivacaine induced ovarian and prostate cancer apoptotic cell death and underlying mechanisms in vitro

Figure 7

GSK-3 inhibitor (SB216763) or GSK-3β siRNA alleviated bupivacaine induced cell death in ovarian cancer (SKOV-3) but not prostate cancer (PC-3) cells.

Cells were treated with 1 mM bupivacaine and 20 μM GSK-3 inhibitor for 24 h. The gene knockdown cells were treated with 1 mM bupivacaine for 24 h. Cell survival of GSK-3 inhibition in (A) SKOV-3 and (B) PC-3 cells. (C) Total GSK-3β expression by western blot. Cell survival of GSK-3β siRNA treatment in (D) SKOV-3 and (E) PC-3 cells. Data are presented as mean ± SD (n = 5). *P < 0.05; **P < 0.01; ***P < 0.001.

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