Figure 8 | Scientific Reports

Figure 8

From: Local anesthetic bupivacaine induced ovarian and prostate cancer apoptotic cell death and underlying mechanisms in vitro

Figure 8

GSK-3β siRNA decreased the expression of caspase 3, 8, 9 and pGSK-3βtyr216.

SKOV-3 cells transfected with siRNA were treated with 1 mM bupivacaine for 24 h. (A) pGSK-3βtyr216 (red) and caspase 8, 9 (green) expression in SKOV-3. (B) pGSK-3βtyr216 (red) and caspase 3 (green) co-expression. (C) The fluorescent intensity analysis of pGSK-3βtyr216 and cleaved caspase 3, 8 and 9. Data are presented as mean ± SD (n = 5). *P < 0.01; **P < 0.001. Scale bar = 50 μm.

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