Table 2 Thermodynamic Binding Constants for inhibitors on Triple Helical Collagen Peptide.

From: Development of antithrombotic nanoconjugate blocking integrin α2β1-collagen interactions

Conditions a

Kd (μM)*

ΔG (kcal/mol)*

ΔH (kcal/mol)*

TΔS (kcal/mol)*

Free LWWNSYY in deionized water

ND

ND

ND

ND

Free LWWNSYY in 25% (v/v) EG

5.52 ± 0.92

−6.77 ± 0.04

1.53 ± 0.24

8.30 ± 0.28

L-PGMA in deionized water

3.45 ± 1.06

−7.09 ± 0.16

1.35 ± 0.21

8.44 ± 0.37

  1. ND, not detectable.
  2. *Data was presented as the mean ± S.D. from three independent experiments (N = 3).
  3. aAll the three conditions contained normal saline concentration.
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