Figure 7
From: RIG-like Helicase Regulation of Chitinase 3-like 1 Axis and Pulmonary Metastasis
RLH activation regulates LIM kinase2 (LIMK2), cofilin, PTEN and BRAF.
WT (a) (+/+) or MAVS null mice (−/−) were given B16 melanoma cells or vehicle and treated with Poly(I:C) or vehicle. Genes associated with the development and progression of malignant melanoma were evaluated 2 weeks later. Western blot evaluation of the activation status of pulmonary cofilin (p-cofilin) and the expression of LIMK2. (b,c) The levels of pulmonary PTEN and BRAF mRNA were evaluated by qRT-PCR. Panel a is representative of a minimum of 3 independent experiment. The values in panels b,c represent the mean ± SEM of evaluations with a minimum of 4 mice. *P < 0.05.
