Figure 1: Time course of Yueju (YJ) and ketamine (KET) mediated antidepressant-like behavioral effects.
From: PKA-CREB-BDNF signaling regulated long lasting antidepressant activities of Yueju but not ketamine
Independent groups of mice were used at each time point and for each drug treatment, to avoid behavioral habituation. (A) Antidepressant activities in KM mice. Analysis of variance (ANOVA) F(2,20) = 60.161, p < 0.0001 for treatment; F(6,210) = 3.374, p < 0.01 for duration of response; F(12,231) = 1.188, p = 0.293 for treatment-duration interaction. Therefore, we examined treatment effects by time point. n = 11/group. (B) Antidepressant activities in ICR mice. Analysis of variance (ANOVA) F(2,11) = 33.893, p < 0.0001 for treatment; F(3,108) = 14.033, p < 0.0001 for duration of response; F(6,120) = 4.471, p < 0.001 for treatment-duration interaction. n = 10/group. *p < 0.05, **p < 0.01, ***p < 0.001, YJ compared to control; #p < 0.05, ##p < 0.01, ###p < 0.001, KET compared to control. Data represent means ± SEM.
