Figure 2: BDNF mRNA in KM or ICR mice as well as protein expression in KM mice after an acute dose of Yueju (YJ) and Ketamine (KET).
From: PKA-CREB-BDNF signaling regulated long lasting antidepressant activities of Yueju but not ketamine
(A) BDNF mRNA expression significantly increased in KM mice at 3 hours (F(2,17) = 108.764, p < 0.05), 1 day (F(2,17) = 17.708, p < 0.05) and 2 days (F(2,17) = 9.499, p < 0.05) after Yueju and ketamine administration. n = 6/group. (B) BDNF mRNA expression increased in ICR mice at 3 hours (F(2,17) = 43.605, p < 0.05) but not at 1 day (F(2,17) = 1.779, p = 0.203) after Yueju or ketamine administration. n = 6/group. (C) BDNF protein expression in KM mice 30 minutes (p < 0.01) or 1 day (p < 0.05) post Yueju and ketamine. n = 5/group. *p < 0.05, **p < 0.01, ***p < 0.001, compared to control. Data represent means ± SEM.
