Figure 5: Effects of mTOR blockade with rapamycin pretreatment on immobility times in the tail suspension test in KM mice and BDNF gene expression 1 day post-Yueju and ketamine.
From: PKA-CREB-BDNF signaling regulated long lasting antidepressant activities of Yueju but not ketamine
(A) The effect of saline (F(2,23) = 18.818, p < 0.001) or rapamycin (F(2,23) = 10.734, p < 0.001) pretreatment on immobility time in the tail suspension test 1 day after Yueju and ketamine treatment in KM mice. n = 8/group. ***p < 0.001, compared to vehicle (VEH, saline); ###p < 0.001, compared to vehicle (rapamycin); &&p < 0.01, compared to KET. (B) The effect of saline (F(2,11) = 34.595, p < 0.001) or rapamycin (F(2,11) = 23.702, p < 0.001) pretreatment on BDNF mRNA expression 1 day after Yueju and ketamine treatment in KM mice. n = 4/group. ***p < 0.001, compared to vehicle (saline); ###p < 0.001, compared to vehicle (rapamycin); &&p < 0.01, compared to KET. Data represent means ± SEM.
