Table 4 The methodological quality of the published literature regarding the tolerance dose of temporal lobe in NPC patients after IMRT.

From: LASSO-based NTCP model for radiation-induced temporal lobe injury developing after intensity-modulated radiotherapy of nasopharyngeal carcinoma

 

Consecutive cohort

Multicolinearity effect

Actuarial rate-based

Selection bias

NTCP model

Ref. 4

Yes

Direct selection (Dmax/D1cc) no MA

No

Yes

Linear

Ref. 7

Yes

Not considered in MA

No

Yes

Linear

Ref. 5

Yes

Not considered in MA

No

Unknown

Not used

Ref. 8

No (only TLI cases)

Not considered in MA

No

—

Not used

Ref. 9

No (1:1 match)

Perform MA for each DVH parameter

No

Yes, serious, maybe

Not used

Ref. 10

Yes

using principal component analysis

No

Yes

Logistic

This study

Yes

using Elastic Net(LASSO)

Yes

No

Logistic/cox

  1. Abbreviations: MA = multivariable analysis; NTCP = normal tissue complication probability; TLI = temporal lobe injury; DVH = dose volume histogram; LASSO = the least absolute shrinkage and selection operator.
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