Figure 10: Circulating and intra-renal RAS. | Scientific Reports

Figure 10: Circulating and intra-renal RAS.

From: Once daily administration of the SGLT2 inhibitor, empagliflozin, attenuates markers of renal fibrosis without improving albuminuria in diabetic db/db mice

Figure 10

(a) Plasma renin activity, and renal cortical (b) renin activity and (c) angiotensin II content in db/m (open) and db/db (grey) mice. Data are (a,b) means ± SEM and (c) median ± IQR with min and max values (n = 5–10). *P < 0.05 vs db/m vehicle, †P < 0.05 vs db/db vehicle, δP < 0.05 vs db/db metformin by one-way ANOVA and Tukey’s post hoc. (c) Analyzed by Kruskal-Wallis one-way ANOVA and no significant differences observed. Comparisons by Student’s unpaired t-test: significance denoted by solid lines and trends denoted by dashed lines.

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