Figure 7: Glomerulosclerosis and mesangial expansion. | Scientific Reports

Figure 7: Glomerulosclerosis and mesangial expansion.

From: Once daily administration of the SGLT2 inhibitor, empagliflozin, attenuates markers of renal fibrosis without improving albuminuria in diabetic db/db mice

Figure 7

(a,b) Periodic acid-Schiff (PAS) stain for glomerulosclerosis, and (c,d) collagen IV and (e,f) fibronectin immunostaining in glomeruli in db/m (open) and db/db (grey) mice. Data are means ± SEM (n = 5–9). *P < 0.05 vs db/m vehicle by one-way ANOVA and Tukey’s post hoc. Comparisons by Student’s unpaired t-test: significance denoted by solid lines and trends denoted by dashed lines.

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