Table 5 Analysis of interactions between mode of delivery and maternal rs355687, neonatal rs3130542 and risk of HBV intrauterine transmission.

From: Genetic variant in CXCL13 gene is associated with susceptibility to intrauterine infection of hepatitis B virus

 

Genotype

Cases

Controls

OR (95% CI) *

P mul

Mothers

 Mode of delivery

 Cesarean section

CT+TT

11 (31.4)

325 (61.4)

1

0.278

 Vaginal delivery

CT+TT

19 (54.3)

145 (27.4)

4.82 (2.09–11.12)

 Cesarean section

CC

4 (11.4)

47 (8.9)

4.63 (1.28–16.69)

 Vaginal delivery

CC

1 (2.9)

12 (2.3)

5.66 (0.60–53.25)

Neonates

 Mode of delivery

 Cesarean section

GG

11 (26.2)

276 (42.3)

1

0.972

 Vaginal delivery

GG

13 (31.0)

135 (20.7)

3.52 (1.26–9.87)

 Cesarean section

AA+AG

10 (23.8)

176 (27.0)

1.93 (0.66–5.64)

 Vaginal delivery

AA+AG

8 (19.0)

66 (10.1)

6.63 (2.04–21.56)

  1. Pmul was calculated using the multiplicative interaction term.
  2. *Adjusted by maternal age, maternal HBeAg and maternal HBV DNA.