Table 6 Transcriptional regulation of oxidative stress-related genes in dog lymphocytes.
From: Evidence supporting the conceptual framework of cancer chemoprevention in canines
Gene | Description | Function | Fold Induction | Pvalue |
|---|---|---|---|---|
Upregulated genes | ||||
CYBB | Cytochrome b-245, beta polypeptide (chronic granulomatous disease) | Antioxidant | 2.26 | 0.051 |
DUSP1 | Dual specificity phosphatase 1 | Oxidative stress responsive gene | 2.68 | 0.023 |
GSR | Glutatione reductase | Oxidative stress responsive gene | 2.34 | 0.016 |
UCP2 | Uncoupling protein 2(mitochondrial, proton cattier) | Superoxide metabolism | 3.54 | 0.044 |
VIMP | Selenoprotein S | Oxidative stress responsive gene | 3.62 | 0.022 |
Downregulated genes | ||||
ATOX1 | ATX1 antioxidant protein | ROS metabolism | −2.83 | 0.048 |
CCL5 | Chemokine (C-C motif) ligand 5 | Oxidative stress responsive gene | −2.28 | 0.018 |
EPX | Eosinophil peroxidase | Antioxidant | −2.43 | 0.046 |
MPV17 | MpV17 mitochondrial inner membrane protein | ROS metabolism | −3.51 | 0.04 |
PRNP | Prion protein | Oxidative stress responsive gene | −2.85 | 0.047 |
SOD3 | Superoxide dismutase 3, extracellular | Antioxidant | −3.28 | 0.035 |
