Figure 5: CASC2 functions as a ceRNA by competitively binding PIAS3-targeting miR-18a. | Scientific Reports

Figure 5: CASC2 functions as a ceRNA by competitively binding PIAS3-targeting miR-18a.

From: The long noncoding RNA CASC2 functions as a competing endogenous RNA by sponging miR-18a in colorectal cancer

Figure 5

(A) The expression of CASC2 and PIAS3 mRNA in CACO2 and HT-29 cells treated with CASC2-siRNA or negative control. The data are presented as the mean ± SD (n = 3), *P < 0.05; Two-sided Student’s t-test. (B) Representative western blot of PIAS3, STAT3, pSTAT3 and c-Myc from CRC cell lines transfected with CASC2-siRNA or negative control. (C) The relationship between CASC2 and PIAS3 in 68 CRC tissues (P < 0.01, R2 = 0.439). The data were obtained using the logistic regression analysis. (D) A schematic model of CASC2 functioning as a decoy by competitively binding miR-18a, upregulating the specific repressor PIAS3 of STAT3 signaling, and suppressing colorectal carcinogenesis.

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