Figure 2: Sortilin interacts with various cytokines. | Scientific Reports

Figure 2: Sortilin interacts with various cytokines.

From: TLR signals posttranscriptionally regulate the cytokine trafficking mediator sortilin

Figure 2

The binding of cytokines to sortilin was measured by surface plasmon resonance analysis. Cytokine binding to immobilized recombinant sortilin was measured with a Biacore X instrument. Sensorgrams of surface plasmon resonance were obtained with various concentrations of recombinant IFN-α (a), IFN-γ (b), IL-6 (c), IL-10 (d), IL-12 (e), IL-17A (f) and IL-1β (g). BSA or GST was used as a negative control. All curves indicate the response after subtraction of non-specific binding, which was determined as the binding of analytes to a BSA-coated flow cell. The mean Kd values ± SEM (n = 3) are shown.

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