Figure 1

Plasma complement activation levels (log-transformed C3d/C3 ratio) for C3, CFH and CFB genotype groups.
Each genotype per SNP is plotted on the X axis in an individual dot plot. The homozygous genotypes conferring increased risk for AMD are indicated in red; the homozygous genotypes that are protective for AMD are indicated in green. The number of individuals carrying a specific genotype is indicated below each genotype. The Y axis represents the Log-transformed C3d/C3 ratio level as a measure of complement activation. The p-values represent the overall significance for each SNP included in the model.