Figure 2 | Scientific Reports

Figure 2

From: Cold-inducible RNA-binding protein causes endothelial dysfunction via activation of Nlrp3 inflammasome

Figure 2

CIRP activates vascular endothelial cells.

(A) Western blot analysis of ICAM-1 in the mouse lung vascular endothelial cells (MLVECs) treated with an indicated concentration of rmCIRP for 4 h. The image shown is representative of three independent experiments. Bars represent mean ± SEM (n = 3) from densitometric analysis of blots. *P < 0.05 compared to no rmCIRP; one-way ANOVA, Student-Newman-Keuls test. (B) Western blot analysis of ICAM-1 in MLVECs treated with 200 ng/ml rmCIRP for upto 8 h as indicated. The image is representative of three independent experiments. Bars represent mean ± SEM (n = 3). *P < 0.05 compared to time 0; one-way ANOVA, Student-Newman-Keuls test.

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