Figure 3: Effects of alternating electric field on breast cancer cells in monoculture or in co-culture with endothelial cells.
From: Engineering a 3D microfluidic culture platform for tumor-treating field application
(A) Cell density and morphology of breast cancer cells (MDA-MB-231) stimulated at a frequency of 150 kHz and intensity of 1.1 V/cm for 3 days. (B) Percentage of caspase dye activation in breast cancer cells (MDA-MB-231) and endothelial cells (HUVEC) stimulated at a frequency of 150 kHz and intensity of 1.1 V/cm. (C) Percentage of Ki-67+ breast cancer cells (MDA-MB-231) and endothelial cells (HUVEC) stimulated at a frequency of 150 kHz and intensity of 1.1 V/cm. Representative images with Ki-67 expression (in red) and blue nuclei. Unpaired t-test, *p < 0.05, n.s = not significant. Scale bars = 100 μm.
