Figure 1 | Scientific Reports

Figure 1

From: An inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis

Figure 1

ITC profile of the titration of the Keap1 Kelch domain with CPUY192018.

The thermodynamic parameters of the interaction of Keap1 with CPUY192018 as determined by the ITC Assay are listed in the table. N is the stoichiometric coefficient. Kd is the binding constant. ΔH, ΔS and ΔG refer to the changes in binding enthalpy, entropy and total Gibbs free energy, respectively. ΔG is calculated according to the equation ΔG = ΔH − TΔS, where T is the absolute temperature used for the ITC experiment.

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