Table 2 Distribution frequency of SERPINB5 genotypes in 590 controls and 302 patients with HCC.
Variables | Controls (N = 590) n (%) | Patients (N = 302) n (%) | OR (95% CI) | AOR (95% CI) |
|---|---|---|---|---|
rs17071138 | ||||
TT | 476 (80.7%) | 228 (75.5%) | 1.00 | 1.00 |
TC | 107 (18.1%) | 70 (23.2%) | 1.366 (0.972–1.919) | 1.367 (0.904–2.068) |
CC | 7 (1.2%) | 4 (1.3%) | 1.193 (0.346–4.117) | 0.832 (0.181–3.834) |
TC + CC | 114 (19.3%) | 74 (24.5%) | 1.355 (0.972–1.890) | 1.330 (0.887–1.992) |
rs3744941 | ||||
CC | 244 (41.4%) | 125 (41.4%) | 1.00 | 1.00 |
CT | 272 (46.1%) | 151 (50.0%) | 1.084 (0.808–1.453) | 1.209 (0.849–1.721) |
TT | 74 (12.5%) | 26 (8.6%) | 0.686 (0.418–1.126) | 0.687 (0.387–1.216) |
CT + TT | 346 (58.6%) | 177 (58.6%) | 0.999 (0.754–1.323) | 1.081 (0.773–1.511) |
rs8089104 | ||||
CC | 166 (28.1%) | 94 (31.1%) | 1.00 | 1.00 |
CT | 275 (46.6%) | 150 (49.7%) | 0.963 (0.698–1.329) | 1.161 (0.791–1.703) |
TT | 149 (25.3%) | 58 (19.2%) | 0.687 (0.463–1.020) | 0.696 (0.433–1.118) |
CT + TT | 424 (71.9%) | 208 (68.9%) | 0.866 (0.640–1.172) | 0.990 (0.692–1.418) |
rs2289519 | ||||
CC | 234 (39.7%) | 123 (40.7%) | 1.00 | 1.00 |
CT | 276 (46.8%) | 140 (46.4%) | 0.965 (0.716–1.300) | 0.970 (0.680–1.384) |
TT | 80 (13.5%) | 39 (12.9%) | 0.927 (0.597–1.441) | 1.056 (0.625–1.785) |
CT + TT | 356 (60.3%) | 179 (59.3%) | 0.957 (0.721–1.269) | 0.989 (0.707–1.382) |
rs2289520 | ||||
GG | 293 (49.7%) | 169 (56.0%) | 1.00 | 1.00 |
GC | 242 (41.0%) | 122 (40.4%) | 0.874 (0.655–1.166) | 0.774 (0.547–1.095) |
CC | 55 (9.3%) | 11 (3.6%) | 0.347 (0.177–0.681)* | 0.247 (0.113–0.543)* |
GC + CC | 297 (50.3%) | 133 (44.0%) | 0.776 (0.588–1.026) | 0.666 (0.477–0.929)* |
rs1455555 | ||||
AA | 180 (30.5%) | 85 (28.1%) | 1.00 | 1.00 |
AG | 295 (50.0%) | 149 (49.4%) | 1.070 (0.773–1.480) | 1.190 (0.807–1.754) |
GG | 115 (19.5%) | 68 (22.5%) | 1.252 (0.843–1.860) | 1.278 (0.795–2.055) |
AG + GG | 410 (69.5%) | 217 (71.9%) | 1.121 (0.825–1.522) | 1.215 (0.842–1.753) |
