Table 4 The estimated haplotype frequencies of six examined polymorphisms in SERPINB5 gene and the corresponding risk for HCC.
Block 1 | Controls (N = 1180) n (%) | Patients (N = 604) n (%) | OR (95% CI) | Pvalue | ||
|---|---|---|---|---|---|---|
rs17071138 T/C | rs3744941 C/T | rs8089104 C/T | ||||
T | C | C | 505 (42.8%) | 256 (42.4%) | Reference | |
T | T | T | 417 (35.4%) | 196 (32.5%) | 0.927 (0.739–1.163) | 0.514 |
T | C | T | 137 (11.6%) | 68 (11.2%) | 0.979 (0.706–1.358) | 0.899 |
C | C | C | 102 (8.6%) | 75 (12.4%) | 1.450 (1.039–2.025) | 0.029 |
Others# | 19 (1.6%) | 9 (1.5%) | 0.934 (0.417–2.095) | 0.869 | ||
Block 2 | Controls (N = 1180) n (%) | Patients (N = 604) n (%) | OR (95% CI) | Pvalue | ||
rs2289519 T/C | rs2289520 G/C | rs1455555 A/G | ||||
T | G | A | 343 (29.1%) | 186 (30.8%) | Reference | |
T | C | A | 332 (28.1%) | 134 (22.2%) | 0.744 (0.569–0.974) | 0.031 |
C | G | A | 264 (22.4%) | 127 (21.0%) | 0.887 (0.673–1.170) | 0.396 |
T | G | G | 167 (14.2%) | 89 (14.7%) | 0.983 (0.719–1.344) | 0.913 |
C | C | G | 54 (4.6%) | 58 (9.6%) | 1.981 (1.313–2.989) | 0.001 |
Others# | 20 (1.6%) | 10 (1.7%) | 0.922 (0.423–2.011) | 0.838 | ||
