Table 1 General characteristics of 13 cohort studies included in the meta-analysis.
From: Anemia increases the mortality risk in patients with stroke: A meta-analysis of cohort studies
First Author | Region | Study design | Age | Follow-up (rate of loss follow-up) | Patients | Sample size | Time from initial symptoms to admission | Anemia (%) | Male/female | Adjustments | Outcome | Criteria for Anemia (Hb) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Liu 2013 | China | Prospective Cohort study | 51–87 | 6 months (4.6%) | Ischemic stroke | 481 | – | 39.40 | 216/243 (0.89) | age, sex, medical treatment, glucose, smoke, hypertension, CAD, history of cardiovascular disease, infection | Death | Male:<130 g/L, female:<120 g/L |
Zheng 2012 | China | Retrospective cohort study | 32–91 | 3 months (0.0%) | hemorrhagic stroke | 101 | – | 0.25 | 65/36 (1.81) | age, gender, SBP, infection, low hemoglobin, recognition, | Death | Male:<130 g/L, female:<120 g/L |
Nybo 2007 | Denmark | Prospective Cohort study | Anemia:73 Non Anemia: 68 | 6 months (0.0%) | Ischemic Stroke | 250 | ≥7 days | 15.00 | 133/117 (1.14) | Age, gender, SSS<30, heart failure and or renal function impaired | Death | Male:<130 g/L, female:<120 g/L |
Kumar 2009 | USA | Prospective Cohort study | 71.3(mean) | 1 month (1.3%) | Acute hemorrhage stroke | 685 | – | 25.80 | 278/307 (0.91) | age, sex, IVH, ICH volume, glucose, WBC, SBP, DBP, warfarin | Death | Male:<130 g/L, female:<120 g/L |
Milionis 2014 | Greece | Prospective Cohort study | Anemia:73.45 Non anemia: 68.82 ± 25.68 | 1 years (0.0%) | acute ischemic stroke | 2439 | – | 17.50 | 1347/1065 (1.26) | age, sex, hemoglobin, C-reaction protein, CAD, NIHSS, | Death | Male:<130 g/L, female:<120 g/L |
Xu 2011 | China | Prospective Cohort study | 68.6 ± 12.2 | 1 month (0.0%) | acute stroke | 1014 | – | 26.30 | 559/455 (1.23) | vascular risk factors, cardiovascular disease, proteinuria, sex, age | Death disability | Male:<130 g/L, female:<120 g/L |
Hao 2013 | China | Prospective Cohort study | Anemia:68.28 Non anemia: 64.35 | 1 year (0.0%) | Ischemic stroke | 1176 | <24 hours | 29.80 | 674/502 (1.34) | age, sex, NIHSS, vascular risk factors renal function | Death disability | Male:<130 g/L, female:<120 g/L |
Huang 2008 | China | Prospective Cohort study | 67.6 | 2 years (9.7%) | Ischemic stroke | 66 | <24 hours | 28.80 | 51/15 (3.4) | Age, sex, presence of IHV, ICH volume, warfarin, glucose, WBC | Death | Male:<120 g/L, female:<110 g/L |
Sico 2011 | India | Retrospective cohort study | 71.5 | 48 hours (0.0%) | ischemic stroke | 1306 | <2 days | 6.40 | 751/555 (1.35) | age, sex, race, medical history, Charlson comorbidity index, score, hematocrit, | Death | Male and female:<100 g/L |
Huang 2009 | China | Prospective Cohort study | Anemia:71.6 No anemia: 6 67.4 | 3 year (4.9%) | Ischemic Stroke | 774 | <2 days | 29.00 | 412/362 (1.14) | age, sex, CKD, CAD, hyperkinemia | Death | Male:<130 g/L, female:<120 g/L |
Tanne 2010 | Israel | Prospective Cohort study | 70.6 | 1 year (0.0%) | Acute stroke | 859 | – | 19.00 | 497/362 (1.37) | age, sex, stroke type, stroke severity, prior disability, CKD, other cardiac disease and malignancy | Death disability | Male:<130 g/L, female:<120 g/L |
Li 2015 | China | Prospective Cohort study | Anemia:68.56 Non anemia: 63.49 | 3 months (0.0%) | acute stroke | 858 | <24 hours | 0.11 | 547/311 (1.76) | age, sex, NIHSS, cardiovascular risk factors, alcohol, tumor | Death | Male:<130 g/L, female:<120 g/L |
Furlan 2015 | Canada | Prospective Cohort study | – | 7days, 1, 3 months | acute stroke | 9230 | – | 24.5% | 4747/4483(1.06) | age, sex, ethnicity, alcohol, cardiovascular risk factors, smoking, history of disease | Death | Male:<140 g/L, female:<120 g/L |
