Figure 4: The effect of GM6001 concentration on spine generation and elimination.
From: Abnormal intrinsic dynamics of dendritic spines in a fragile X syndrome mouse model in vivo
(a,b) Spine generation (a) and elimination (b) rates during 2-day intervals in wild-type mice with a glass window and intraperitoneal (i.p.) injection of GM6001 at 0 mg/kg, 5 mg/kg (eight intervals, five cells, five mice, 598 spines), 10 mg/kg, 20 mg/kg (seven intervals, five cells, five mice, 721 spines), or 50 mg/kg (eight intervals, five cells, three mice, 692 spines). The number on each bar in (a,b) indicates the number of intervals analyzed. The same data are displayed in Fig. 2g,h with regard to 0 mg/kg and 10 mg/kg. Spine generation and elimination rates between each imaging session were averaged within each group. Kruskal–Wallis test, p < 0.01 in (a) and p = 0.79 in (b). *p < 0.05, **p< 0.01 using a Steel’s test with respect to 0 mg/kg.
