Figure 8
From: Novel chitosan/diclofenac coatings on medical grade stainless steel for hip replacement applications
The results of in vitro drug release testing with the corresponding 95% confidence intervals: (a) DCF concentration as a function of time, (b) shows a schematic depiction of the proposed release scenario in light of the obtained results and the calculation of first derivatives, (c) the cumulative mass of released DCF as a function of time and (d) the % of released DCF as a function of time. The shown mass in (c) represents the mass in 1 ml of the withdrawn sample from 15 ml of dissolution media. In order to calculate the overall released mass, therefore, a factor of 15 of needs to be accounted for. First derivatives, calculated from cumulative DCF released mass and the % of released DCF, were added to (c) and (d) respectively.
