Table 3 Calculated DCF amounts on a hypothetical artificial hip.

From: Novel chitosan/diclofenac coatings on medical grade stainless steel for hip replacement applications

 

Head only

Neck only

Whole artificial hip

Artificial hip surface area (based on REF) (mm2)

13,000–23,000

17,000–27,000

30,000–50,000

Calculated possible amount of DCF released with the same composition as in the 3CHI2DCF-coated sample (mg)

3.2–5.6

4.0–6.6

7.2–12.2

Calculated possible amount of DCF released with the same composition as in the 3CHI3DCF-coated sample (mg)

3.6–6.4

4.6–7.4

8.2–13.8

SAFE DAILY DCF DOSES

Treatment

Safe daily dose (mg)

Safe daily dose based on BU of 55% (mg)

 

Dysmenorrhea/migraine/general pain treatment (lowest daily doses)101

50

27.5

 

Rheumatoid arthritis treatment (highest daily doses)101

225

123.75

 
  1. Average male and female daily doses of DCF are presented at the bottom of the table for comparison101. The surface area of the AISI 316LVM stainless steel substrate is 706.9 mm2.
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