Figure 2 | Scientific Reports

Figure 2

From: RETRACTED ARTICLE: MiRNA-211 suppresses cell proliferation, migration and invasion by targeting SPARC in human hepatocellular carcinoma

Figure 2

Overexpression of miR-211 inhibits cell proliferation in vitro.

(A) Real-time RT-PCR analysis of the expression levels of miR-211 in 97H and LM3 cells stably expressing miR-211. (B) Cell proliferation rate of 97H and LM3 cells transfected with vector or miR-211by MTT assay. (C) Representative photographs (left) and relative quantification (right) of colony formation were counted in an anchorage-independent growth ability assay. (D) Cell apoptosis was assessed by flow cytometric analysis in 97H and LM3 cells. (E) Overexpression of miR-211 inhibited tumor growth in vivo. Representative tumor xenografts excised from nude mice administered a subcutaneous injection of LM3-vector or LM3-miR-211 (left). Quantification of tumor mass weight (right). Data are presented as the mean ± SD. (F) Representative immunohistochemical staining of Ki67 in tumor xenografts excised from nude mice. **P < 0.01.

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