Table 1 Uremic toxins inhibit OAT1- and OAT3-mediated fluorescein uptake.

From: Bioengineered kidney tubules efficiently excrete uremic toxins

Uremic toxin

Cm (μM) in ESRD patients1

ciPTEC-OAT1 (IC50 - μM)

R square

ciPTEC-OAT3 (IC50 - μM)

R square

Indoxyl sulfate

110

25 ± 4

0.92

83 ± 41

0.42

l-Kynurenine

6

65 ± 8

0.92

219 ± 66

0.54

Kynurenic acid

1

6 ± 1

0.95

6 ± 1

0.83

Indole-3-acetic acid

4

19 ± 2

0.93

148 ± 60

0.49

Hippuric acid

398

5 ± 1

0.95

22 ± 9

0.78

Indoxyl-β-glucuronide

9

492 ± 68

0.67

527 ± 218

0.55

p-Cresylglucuronide

44

2650 ± 922

0.28

588 ± 81

0.36

p-Cresylsulfate

675

79 ± 14

0.84

112 ± 19

0.80

  1. The eight tested anionic uremic toxins inhibit OAT1- and OAT3-mediated fluorescein uptake in a concentration-dependent manner. Mean plasma levels of uremic toxins in ESRD patients were extracted from Duranton et al.6. R square: goodness of fit values extracted from non-linear regression analysis.
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