Figure 4
From: The Magea gene cluster regulates male germ cell apoptosis without affecting the fertility in mice
Magea proteins prevented an excessive apoptotic response in germ cells in an acute manner after ENU-induced genotoxic stress.
(A) Time course flow cytometry analysis of testicular apoptosis in C57BL/6J mice after exposure to ENU. The results are shown at several time points (in days) as indicated. (B) Quantification of apoptosis after exposure to ENU for 1 week (n = 4 for each time point). (C,D) Detection of testicular apoptosis by flow cytometry analysis at 12 hours and 24 hours after exposure to ENU (60 mg/kg) (12 hours, n = 4 for wild type and n = 5 for Magea−/Y; 24 hours, n = 6 for wild type and n = 4 for Magea−/Y). *p < 0.05.
