Figure 3 | Scientific Reports

Figure 3

From: Structural Brain Alterations Associated with Rapid Eye Movement Sleep Behavior Disorder in Parkinson’s Disease

Figure 3

Volume change comparison between PD patients with (pRBD) and without (noRBD) probable RBD and healthy controls (HC).

Thresholded t maps (at P < 0.05 corrected for multiple comparisons) superimposed onto Montreal Neurological Institute 152 brain imaging template. The color-coded bar represents t values and the display is thresholded at P < 0.05. (A) DBM group comparison between pRBD and HC showing areas of significantly smaller volume in pRBD in sub-cortical and cortical regions. Top, sagittal plane showing smaller volumes in the PMT (arrow), the ventral medulla (arrow head) and the anterior cingulate (dashed arrow). Middle, coronal plane showing smaller volumes in the substantia nigra (arrow), the hippocampus (arrow head) and the thalamus (dashed arrow). Bottom, axial plane showing smaller volumes in the putamen (arrow), the hypothalamus (arrow head) and the lingual gyrus (dashed arrow). (B) DBM group comparison between noRBD and HC showing areas of significantly smaller volume in noRBD, encompassing the substantia nigra (arrows).

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