Table 1 Protection of C57BL/6 mice immunized in a 3-shot regimen with the indicated strains against challenge with wildtype P. berghei ANKA sporozoites or blood stages).
From: Protective efficacy and safety of liver stage attenuated malaria parasites
Exp. | Attenuated parasite line (P. berghei ANKA) | 1st shot | 2nd and 3rd shots * (day of shots) | Challenge dose # (day of challenge) | Protected/challenged animals (pre-patency) + | |
|---|---|---|---|---|---|---|
Challenge 1 | Challenge 2 | |||||
1 | LISP2(–) | 10.000 | 10.000 (d14, d28) | 1.000 (d42) | 10.000 (d116) | C1: 3/4 (d 6), C2: 1/1 |
5.000 bs (d116) | C2: 0/2 (d 4.5) | |||||
1.000 | 0/4 (d 3) | |||||
2 | LISP2 (–) | 50.000 | 20.000 (d14, d28) | 10.000 (d42) | 10.000 (d102) | C1 : 4/4, C2 : 2/2 |
10.000 bs(d102) | C2 : 0/2 | |||||
uis3(–) | 50.000 | 20.000 (d14, d28) | 10.000 (d42) | 10.000 (d102) | C1: 6/6 ** , C2: 6/6 | |
LISP2(–)/uis3(–) | 50.000 | 20.000 (d14, d28) | 10.000 (d42) | 10.000 (d102) | C1: 8/8, C2: 8/8 | |
10.000 | 0/8 (d 3.1) | |||||
