Table 2 Protection of C57BL/6 mice immunized in a 2-shot regimen with the indicated P. berghei ANKA knockout lines against challenge with wild type P. berghei ANKA sporozoites or blood stages.
From: Protective efficacy and safety of liver stage attenuated malaria parasites
Exp. | Attenuated parasite line (P. berghei ANKA) | 1st shot | 2nd shot * (day14) | Challenge dose # (day of challenge) | Protected/challenged animals (pre-patency) |
|---|---|---|---|---|---|
3 | LISP2(–) | 10.000 | 10.000 | 1.000 (d42) | 1/4 (d 5.75) |
1.000 (d42) | 0/4 (d 3) | ||||
4 | LISP2(–) | 20.000 | 20.000 | 10.000 (d28) | 8/8 |
uis3 (–) | 20.000 | 20.000 | 10.000 (d28) | 3/7 ** (8.75 d) | |
LISP2(–)/uis3(–) | 20.000 | 20.000 | 10.000 (d28) | 3/8 (8.6 d) | |
10.000 (d28) | 0/4 (3.75 d) |
