Figure 1 | Scientific Reports

Figure 1

From: Donor CD47 controls T cell alloresponses and is required for tolerance induction following hepatocyte allotransplantation

Figure 1

Skin allograft survival in mice receiving WT or CD47KO hepatocyte transplantation.

WT B6 mice received sham-operation (Sham) or hepatocyte transplantation from WT or CD47KO OVA-Tg B6 donors, followed 7 days later by WT-OVA-Tg B6 mouse skin transplantation. Some recipient mice also received third-party (BALB/c) mouse skin grafts at the same time. (A) OVA-Tg mouse skin graft survival. (B) Third-party mouse skin graft survival. (C) OVA-Tg mouse skin grafts were harvested for histological analysis from the recipients of WT (top) or CD47KO (bottom) hepatocytes 13 days after skin transplantation. Shown are representative samples stained with HE and IHC (with anti-CD4 or anti-CD8).

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