Figure 4 | Scientific Reports

Figure 4

From: Donor CD47 controls T cell alloresponses and is required for tolerance induction following hepatocyte allotransplantation

Figure 4

MDSC expansion contributes to tolerance induction by hepatocyte transplantation.

B6 mice received sham operation (Sham) or transplantation of WT-OVA-Tg B6 mouse hepatocytes without (HTx) or with gemcitabine treatment (HTx + Gem), followed 7 days later by OVA-Tg mouse skin transplantation (n = 5–9/group). (A) Representative staining profiles (top) and percentages (mean ± SDs; bottom) of CD11b+ Gr1+ MDSCs in PBMCs analyzed by flow cytometry 2 days after hepatocyte transplantation. *p < 0.05, ***p < 0.001. (B) Skin graft survival.

Back to article page