Figure 1
From: Ring-Shaped Microlanes and Chemical Barriers as a Platform for Probing Single-Cell Migration
Cell migration in ring-shaped micropatterns.
(a) Fluorescence image of the pattern consisting of labeled fibronectin (bright) and PLL-PEG (dark). (b) Time-lapse series of phase-contrast images of a MDA-MB-436 cell migrating along a ring-shaped lane. The fluorescently labeled nucleus is indicated in blue. Cell morphologies predominantly fall into two classes: asymmetrically polarized cells with a single lamellipodium at the leading edge and the nucleus located at the posterior end and elongated cells with two, symmetrically positioned lamellipodia.
