Figure 2: Characterization of the conditional elimination of RBP-Jκ in the Ngn3 progenitors.
From: Early pancreatic islet fate and maturation is controlled through RBP-Jκ
(a) Immunostaining for RBP-Jκ (red), Insulin (blue) and YFP (green) in control and RBP-Jκ adult mice. The lower panel shows immunostaining for RBP-Jκ alone. (b) Fasting blood glucoses in 3 months-old control, Presenilin and RBP-Jκ male mice. (c) IPGTT in control, Presenilin and RBP-Jκ male mice. (d) ITT in control, Presenilin and RBP-Jκ male mice as a percentage compared to t0. (e) Immunostaining for Amylase (red), Insulin (blue) and EGFP (green) in the RBP-Jκ mice. (f) Pancreas weights for the control and RBP-Jκ mice at approximately 3 months of age. Scale bars = 50 μm.
