Figure 8: Diagram of the control of the endocrine fate by RBP-Jκ.
From: Early pancreatic islet fate and maturation is controlled through RBP-Jκ
During development, deleting RBP-Jκ from Ngn3 progenitors blocks Notch signaling but doesn’t push the cells towards the acinar fate since the Ptf1a/RBP-Jκ complex cannot form and promote the acinar differentiation pathways. Some of the Notch-deleted, Ngn3 progenitors fail to differentiate express high levels of Sox9 and form disorganized masses.
