Figure 4: Hypothetical mechanisms of NAT inhibition by apocynin. | Scientific Reports

Figure 4: Hypothetical mechanisms of NAT inhibition by apocynin.

From: Treatment of Rats with Apocynin Has Considerable Inhibitory Effects on Arylamine N-Acetyltransferase Activity in the Liver

Figure 4

(a) Tautomers of apocynin (1). (b) Possible Michael addition between Cys68 thiolate and apocynin quinonemethide tautomer (2) within NAT active site. Cys68, His107 and Asp122 constitute the catalytic triad in mammalian NAT enzymes46,47. (c) Possible interaction between exposed thiols groups of NATs and radical apocynin metabolites (3).

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