Figure 6: Application of 5-NOT, colominic acid and vinorelbine increases number of myelin lamellae and cross-sectional area of axons.
From: The polysialic acid mimetics 5-nonyloxytryptamine and vinorelbine facilitate nervous system repair
Electron microscopic images show axons 10 μm caudal to the lesion site in transverse spinal cord sections. Number of myelin lamellae (mean values ± SEM, n = 4 per group) around axons, the cross-sectional area of axons (mean values ± SEM, n = 4 per group), axon diameters (mean values ± SEM, n = 4 per group), numbers of myelinated fibers (mean values ± SEM, n = 4 per group) and astrocytic surface area (mean values ± SEM, n = 4 per group) in 5-NOT, vinorelbine and colominic acid (CA) treated mice as compared to vehicle control. (*p < 0.05, one-way ANOVA with Holm-Sidak post-hoc test). Arrows denote astrocytic processes. Scale bar: 2 μm.
