Figure 2 | Scientific Reports

Figure 2

From: Hyperlipidemia-associated gene variations and expression patterns revealed by whole-genome and transcriptome sequencing of rabbit models

Figure 2

Deleterious mutations in WHHL rabbits.

(a) Proportion of deleterious mutation by difference in allele frequency (ΔAF) between WHHL and NZW or JW rabbits. (b) Putative deleterious mutations in WHHL rabbits with ΔAF > 0.7 compared with both normal rabbits. Colors show the density of SNPs from high (red) to low (blue). Genes harboring deleterious mutations are highlighted. (c) Non-synonymous mutations in ALDH2. The red cross indicates the locations of mutations. R99C is a putative deleterious mutation in WHHL rabbits. E487K is a known loss-of-function mutation in humans. Both mutations occur at highly conserved sites across vertebrates.

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