Figure 4
Differences in hepatic transcriptome profiles of Chol-fed and WHHL rabbits.
(a) No positive correlation of DEGs in the liver between Chol-fed and WHHL rabbits. The correlation coefficient was calculated for DEGs for at least one condition. (b) Heatmap of representative DEGs responsible for inflammatory responses in the liver. The read counts were log-transformed and normalized across samples. These genes were activated in Chol-fed but not in WHHL rabbits. (c) Transcriptional regulatory network of lipid metabolism in the liver. The left semicircle of each gene shows the log2-fold change of WHHL compared with JW rabbits, while the right semicircle shows the log2-fold change of Chol-fed compared with normal chow-fed rabbits. Gradient colors indicate over-expression (red) or under-expression (green). Grey indicates fold change <1.5. Lines with arrowheads denote activation and lines with crossings denote inhibition. Key transcription factors were enriched in the Chol-fed rabbits, but none were enriched in the WHHL rabbits.
