Figure 2

Serum analytes elevated significantly in (A) females and (B) males. Robust regression was used where *follows the analyte name. The log₂ ratios of serum molecular concentrations in males compared to females shown in the plots were coefficients from the linear regression. Analytes in the plots are coloured in red where sex differences varied significantly with female hormonal status. Agreement with the validation cohort and our previous study is shown by a ✓ in the last columns. NM was used to indicate that the analyte was not measured in our previous study. To the right of the plots, biomarkers of schizophrenia (SCZ), major depressive disorder (MDD) and cancer are indicated by ↑ (elevated in patients); ↓ (reduced in patients); or × (conflicting evidence for elevated and reduced levels in patients). Analyte abbreviations can be found in Supplementary Table 1.