Figure 6 | Scientific Reports

Figure 6

From: Medial plantar nerve ligation as a novel model of neuropathic pain in mice: pharmacological and molecular characterization

Figure 6

Pharmacological predictivity of pain-like behaviours after MPNL.

At 3 or 14 days after MPNL, mice were treated systemically with (A,B) dexamethasone (2 mg/kg; s.c), (C,D) indomethacin (5 mg/kg, i.p), (E,F) morphine (5 mg/kg, i.p) or (G,H) gabapentin (100 mg/kg). The withdrawal threshold was measured using von Frey filaments after treatment. The data are presented as the mean ± S.E.M. (n = 5 per group). Time 0 represents the baseline before pharmacological treatments. ***P < 0.001 and **P < 0.01 to *P < 0.05 indicates a statistically significant difference when compared with the vehicle treated group.

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