Figure 8 | Scientific Reports

Figure 8

From: Medial plantar nerve ligation as a novel model of neuropathic pain in mice: pharmacological and molecular characterization

Figure 8

MPNL-induced pain-like behaviours depend on astrocyte activation.

(A) The lumbar spinal cord samples were collected at indicated times after MPNL or sham. The GFAP protein expression was measured using western blotting (representative blotting and analyses; n = 4 per group). (B) The mice (n = 5 per group) were treated with fluorocitrate (i.t., 1–3 nmol/site) 7 days after MPNL and the withdrawal threshold was assessed before and up to 48 h after fluorocitrate treatment. The data are presented as the mean ± S.E.M. ***P < 0.001 and **P < 0.01 indicates a statistically significant difference when compared with the sham or vehicle treated group.

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