Figure 2
From: The NKD1/Rac1 feedback loop regulates the invasion and migration ability of hepatocarcinoma cells
NKD1 inhibits HCC cell invasion and migration is dependent on Rac1.
(A) Ectopic expression of NKD1 in SMMC-7721 and Huh7 cells decrease the Rac1 protein activity along with decrease of the quantification of Rac1, whereas it had no effect on Rac1 mRNA levels. (B) NKD1 over-expression-mediated inhibition of the invasion and migration of HCC cells was strongly restored by the expression of Rac1. (C) The cytoskeletal rearrangement of SMMC-7721 with NKD1 over-expression group was less than that with the control group. However, this weakness was strongly restored with the over-expression of Rac1. (*P < 0.05; **P < 0.01).
