Table 3 Antiproliferative activities of VLX1570, b-AP15 and bortezomib on multiple myeloma cells.

From: The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells

Compound

VLX1570

b-AP15

bortezomib

KMS-11

43 ± 2

83 ± 3

67 ± 3

RPMI8226

74 ± 2

150 ± 14

84 ± 5

OPM-2

126 ± 3

160 ± 3

32 ± 1

OPM-2-BZR

191 ± 1

268 ± 12

204 ± 10

  1. Shown in this table are IC50 values in nanomolar (nM) determined over 72 hours using the MTT assay.
Back to article page