Figure 3: Visualization of proteasome activity in KrasG12D-mediated PanIN lesions.
From: Proteasome activity is required for the initiation of precancerous pancreatic lesions
(a) H&E staining, Alcian blue staining, and fluorescence imaging of the pancreas of Gdeg;Pdx-1-Cre;LSL-KrasG12D mice with or without caerulein treatment. Mice were intraperitoneally injected with caerulein or PBS, and analyzed on day 28 (n = 4). Dashed lines on the fluorescence images mark PanIN lesions. Bar, 100 μm. (b) Quantification of Alcian blue positive areas in each group. Values are shown as mean ± SD.
