Figure 4: Suppression of KrasG12D -mediated PanIN formation under proteasome inhibition. | Scientific Reports

Figure 4: Suppression of KrasG12D -mediated PanIN formation under proteasome inhibition.

From: Proteasome activity is required for the initiation of precancerous pancreatic lesions

Figure 4

(a) H&E staining, Alcian blue staining, fluorescence imaging, and immunofluorescence staining for amylase and cytokeratin19 (CK19) of the pancreas of caerulein-treated Gdeg;Pdx-1-Cre;LSL-KrasG12D mice with or without MG132 administration (n = 3). Dashed lines on the fluorescence images mark PanIN lesions. Bar, 100 μm. (b) Quantification of Alcian blue positive areas in each group. Values are shown as mean ± SD.

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