Figure 5: Expression of Ras signaling-related proteins in PanIN lesions under proteasome inhibition. | Scientific Reports

Figure 5: Expression of Ras signaling-related proteins in PanIN lesions under proteasome inhibition.

From: Proteasome activity is required for the initiation of precancerous pancreatic lesions

Figure 5

(a) Immunofluorescence staining for pERK, cyclin D1, Ki67, NF-κB, Cox2, Shh, Sox9, and β-catenin of the pancreas of caerulein-treated Gdeg;Pdx-1-Cre;LSL-KrasG12D mice with or without MG132 administration (n = 3). Dashed lines on the fluorescence images mark PanIN lesions. Bar, 100 μm. (b) Quantification of the positive staining rates of pERK, cyclin D1, Ki67, NF-κB, Cox2, Shh, Sox9, and β-catenin at day 28. Values are shown as mean ± SD.

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