Table 2 Viral mRNA and protein expression in HeLa cells lines expressing EGS C468-A, C468-I, SER-A and SER-I, respectively, presented as the percentages of inhibition compared to those in the parental HeLa cells.

From: Inhibition of herpes simplex virus 1 gene expression and replication by RNase P-associated external guide sequences

Viral gene

Gene class

HeLa

SER-I

C468-I

SER-A

C468-A

ICP4 mRNA

IE

0%

6%

9%

77 ± 7%

97 ± 8%

ICP47 mRNA

IE

0%

0%

1%

1%

2%

TK mRNA

Early

0%

2%

2%

78 ± 6%

96 ± 9%

ICP4 protein

IE

0%

7%

8%

75 ± 7%

97 ± 8%

ICP27 protein

IE

0%

3%

3%

2%

1%

gC protein

Late

0%

1%

2%

77 ± 8%

95 ± 7%

ICP35 protein

Late

0%

0%

1%

77 ± 8%

95 ± 9%

gB protein

Late

0%

1%

2%

75 ± 7%

97 ± 8%

  1. The values represent arithmetic means of triplicate experiments and the values of standard deviation which were less than 5% are not shown.
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