Figure 6: MK-1064 dose-dependently promotes somnolence and attenuates arousal in healthy human subjects.
From: Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man
(a) Plasma concentration of MK-1064 over time following administration of single doses of MK-1064 5–250 mg. (b) Somnolence, as measured by the KSS, and (c) alertness, as measured by the Bond and Lader VAS, over time following administration of single doses of MK-1064 (5–250 mg) or placebo in healthy human subjects (N = 20).
